Category: Virology
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SFTSV NSs interacts with AGO2 to regulate the RNAi pathway for viral replication
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Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection
Abstract The Crimean-Congo hemorrhagic fever virus (CCHFV) causes Crimean-Congo hemorrhagic fever (CCHF), a widely distributed disease with significant morbidity and mortality. The virus has high genetic diversity correlated with geographic distribution but limited temporal evolution within regions. Despite this, cases of CCHF within a region present as a spectrum of disease from often unrecognized asymptomatic… Continue reading Host genetic diversity contributes to disease outcome in Crimean-Congo hemorrhagic fever virus infection
Author Correction: Dominant HPAIV H5N1 genotypes of Germany 2021/2022 are linked to high virulence in Pekin ducklings
Correction to: npj Viruses https://doi.org/10.1038/s44298-024-00062-0, published online 06 November 2024 In this article, the funding statement from the European Union (WiLiMan-ID, grant agreement 101083833) was omitted. The original article has been corrected. Author informationAuthors and Affiliations Friedrich- Loeffler- Institute, Institute of Diagnostic Virology, Greifswald, Germany Ronja Piesche, Anne Pohlmann, Ann Kathrin Ahrens, Martin Beer, Timm Harder & Christian Grund Friedrich- Loeffler-… Continue reading Author Correction: Dominant HPAIV H5N1 genotypes of Germany 2021/2022 are linked to high virulence in Pekin ducklings
Molecular basis of host recognition of human coronavirus 229E
Abstract Human coronavirus 229E (HCoV-229E) is the earliest CoV found to infect humans. It binds to the human aminopeptidase N (hAPN) through the receptor binding domain (RBD) of its spike (S) protein to achieve host recognition. We present the cryo-electron microscopy structure of two HCoV-229E S protein in complex with a dimeric hAPN to provide… Continue reading Molecular basis of host recognition of human coronavirus 229E
Immunity against seasonal H1N1 flu reduces bird flu severity in ferrets, study suggests
Pre-existing immunity against seasonal H1N1 flu might help explain why most reported human cases of H5N1 bird flu in the U.S. have not resulted in lethal outcomes.