By David Tuller, DrPH In January, the Journal of Family Medicine and Primary Care published a paper from New Zealand called “An audit of 12 cases of long COVID following the lightning process intervention examining benefits and harms.” It reads like a Lightning Process marketing effort cosplaying as an academic study. As a reminder, the… Continue reading Trial By Error: New Hyped-Up Lightning Process Study from New Zealand
Category: Virology
TWiV 1197: The long and short of influenza
TWiV reviews passing of Ann Palmenberg, deadly illness in western Congo, US disruption of mpox and ebolavirus programs, first measles death in Texas outbreak, flu vaccine selection meeting postponed, US withdraws from polio, malaria, HIV programs and more, clade 2.3.4.4b H5N1 viruses have a long HA stalk, and systems vaccinology to identify predictors of durable… Continue reading TWiV 1197: The long and short of influenza
Trial By Error: Some Things I’ve Read Recently…
By David Tuller, DrPH With so many people impacted by Long Covid and ME/CFS, it is impossible to keep up with all the non-academic articles, posts, and commentaries out there. The gusher of material is really overwhelming. Given that, sometimes it seems worthwhile to highlight a few things worth reading. (Note: Recommending something as worth… Continue reading Trial By Error: Some Things I’ve Read Recently…
TWiV 1196: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello lament about the downfall of public health from “postponement” of the advisory committee on immunization practices and the FDA VRBPAC influenza strain selection meetings to how the communication pause prevents public notice of NIH study section meetings, and withdrawal of CDC promotions for the ‘flu… Continue reading TWiV 1196: Clinical update with Dr. Daniel Griffin
Trial By Error: Trudie Chalder Is Co-Author on Another Bad Exercise Paper
By David Tuller, DrPH It is a truth universally acknowledged (or at least universally acknowledged by smart researchers), that if the list of authors on an article includes Trudie Chalder, King’s College London’s mathematically and factually challenged professor of cognitive behavior therapy, then the article in question should most assuredly be expected to be short on, or utterly devoid of,… Continue reading Trial By Error: Trudie Chalder Is Co-Author on Another Bad Exercise Paper
Porcine reproductive and respiratory syndrome virus nsp5 inhibits the activation of the Nrf2/HO-1 pathway by targeting p62 to antagonize its antiviral activity
A single residue in domain II of envelope protein of yellow fever virus is critical for neutralization sensitivity
Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis
Abstract Long-term consequences of SARS-CoV-2 infection affect millions of people and strain public health systems. The underlying pathomechanisms remain unclear, necessitating further research in appropriate animal models. This study aimed to characterize the trajectory of lung regeneration over 112 days in the male hamster model by combining morphological, transcriptomic and functional readouts. We demonstrate that… Continue reading Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis
Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency
Abstract HIV-1 latency is mainly characterized at transcriptional level, and little is known about post-transcriptional mechanisms and their contribution to reactivation. The viral protein Rev controls the nucleocytoplasmic export of unspliced and singly-spliced RNA that is central to proviral replication-competence and is therefore a prerequisite for efficient viral reactivation during the “shock-and-kill” cure therapy. Here… Continue reading Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency
Establishment and validation of a dynamic nomogram to predict short-term prognosis and benefit of human immunoglobulin therapy in patients with novel bunyavirus sepsis in a population analysis study: a multicenter retrospective study
This study aims to develop a dynamic nomogram model using machine learning to improve short-term prognosis prediction and identify patients who would benefit from intravenous immunoglobulin (IVIG) therapy. Continue reading on BioMed Central