Abstract Human cytomegalovirus (HCMV) encodes four viral Fc-gamma receptors (vFcγRs) that counteract antibody-mediated activation in vitro, but their role in infection and pathogenesis is unknown. To examine their in vivo function in an animal model evolutionarily closely related to humans, we identified and characterized Rh05, Rh152/151 and Rh173 as the complete set of vFcγRs encoded… Continue reading Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity
Category: Virology
Antibody treatment prevents severe bird flu in monkeys
The antibody targets a stable part of the bird flu virus, ensuring that the immune protection can resist new variants and offer long-term protection against the globally spreading airborne infection.
Zika uses human skin as ‘mosquito magnet’ to spread virus further
Zika virus hijacks the skin of its human host to send out chemical signals that lure more mosquitoes to infect and spread the disease further, new research shows.
Pasteurization temperatures effectively inactivate Rift Valley fever viruses in milk
A yeast-based reverse genetics system to generate HCoV-OC43 reporter viruses encoding an eighth subgenomic RNA
Trial By Error: Norwegian Long Covid Rehab Trial Misrepresents Clinically Insignificant Findings As “Effective”
By David Tuller, DrPH If the results for a trial’s primary outcome do not meet the threshold for what is considered a “clinically significant” benefit, it goes without saying—or at least it should–that investigators have no legitimate grounds for promoting their intervention as “effective.” This is especially true when the trial in question is unblinded… Continue reading Trial By Error: Norwegian Long Covid Rehab Trial Misrepresents Clinically Insignificant Findings As “Effective”
Pasteurisation temperatures effectively inactivate influenza A viruses in milk
Abstract In late 2023 an H5N1 lineage of high pathogenicity avian influenza virus (HPAIV) began circulating in American dairy cattle Concerningly, high titres of virus were detected in cows’ milk, raising the concern that milk could be a route of human infection. Cows’ milk is typically pasteurised to render it safe for human consumption, but… Continue reading Pasteurisation temperatures effectively inactivate influenza A viruses in milk
Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1
Abstract Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of specific treatments or antiviral drugs available. This study investigated the potential repurposing of domperidone, an antiemetic and gastrokinetic agent, to control DENV infection. Domperidone was identified by pharmacophore-based virtual screening… Continue reading Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1