This diagnostic study investigates whether an artificial intelligence model can be trained to interpret clinical encephalograms similar to human experts.
Category: Neuroscience
Rituximab vs Ocrelizumab in Relapsing-Remitting Multiple Sclerosis
AI SummaryThis cohort study compares the effectiveness of rituximab and ocrelizumab in preventing relapses and disability in patients with relapsing-remitting multiple sclerosis.This cohort study investigates if rituximab is noninferior to ocrelizumab in the prevention of relapses and disability in patients with relapsing-remitting multiple sclerosis.
Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment
AI SummaryThis randomized clinical trial examines the safety and effectiveness of ApTOLL as a neuroprotectant drug when combined with endovascular treatment for patients with ischemic stroke.This randomized clinical trial investigates the safety and efficacy of ApTOLL as a neuroprotectant drug for patients with ischemic stroke when given in combination with endovascular treatment.
Segmental Uniparental Isodisomy and “Inside-to-Outside” Limb-Girdle Muscular Dystrophy
This case report describes segmental uniparental isodisomy causing an “inside-to-outside” limb-girdle muscular dystrophy due to a homozygous mutation in POGLUT1.
Error in Figure 3
AI SummaryThe wrong image was published for Figure 3 in the Original Investigation titled “Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes.” The article has been corrected online.In the Original Investigation titled “Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes,” which was published… Continue reading Error in Figure 3
A Call to Action to Address Sex Differences in Alzheimer Disease Clinical Trials
This Viewpoint calls for comprehensive investigations into sex differences associated with treatments in existing Alzheimer disease and integration into future Alzheimer disease and related dementia clinical trials.
Error in Figure 2
In the Original Investigation titled “Effectiveness of Lumbar Cerebrospinal Fluid Drain Among Patients With Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical Trial,” published online June 18, 2023, there was an error in the lumbar drain group in Figure 2. The value was updated from 24 to 9 for the group with a modified Rankin Scale score… Continue reading Error in Figure 2
[Comment] NfL is ready for translation into paediatrics
Diagnostic and therapeutic advancements for neurological conditions will be aided by progress in biomarker research across the age span. Ultrasensitive detection assays for neurofilament light chain (NfL) have emerged as validated soluble protein measures of neuroaxonal injury.1 Abnormally elevated blood and CSF concentrations of NfL correlate with the extent of CNS injury (providing prognostic and… Continue reading [Comment] NfL is ready for translation into paediatrics
[Articles] Serum neurofilament light chain reference database for individual application in paediatric care: a retrospective modelling and validation study
AI SummaryThe use of sNfL Z score in children and adolescents allows for more accurate estimation of neuroaxonal damage in individual patients than absolute sNfL values. Summary unavailable.The established normative sNfL values in children and adolescents provide a foundation for the clinical application of sNfL in the paediatric population. Compared with absolute sNfL values, the… Continue reading [Articles] Serum neurofilament light chain reference database for individual application in paediatric care: a retrospective modelling and validation study
Play and tickling responses map to the lateral columns of the rat periaqueductal gray
Play is critical for the well-being of humans and many animals. Gloveli et al. find that rat periaqueductal gray neurons are modulated by tickling and play. Inactivation of the periaqueductal gray leads to impaired play and ticklishness, indicating a role for the midbrain in playfulness.