Category: Neuroscience

[Comment] Important considerations for children with non-dystrophic myotonia

AI SummaryThe text discusses the challenges in diagnosing and treating rare neurological disorders such as non-dystrophic myotonias, caused by mutations in skeletal muscle ion channels. These disorders lead to episodic muscle stiffness due to altered muscle membrane excitability. Clinical research in this field is difficult, resulting in unmet medical needs. The importance of considering these… Continue reading [Comment] Important considerations for children with non-dystrophic myotonia

[Comment] Targeting auto-antibodies for CIDP: hope and questions

AI SummaryThis article discusses the challenges in treating chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) despite the availability of evidence-based treatments such as intravenous immunoglobulins, plasma exchange, and corticosteroids. These treatments may improve function in some individuals but not all, and other agents have not shown benefits in trials. The article highlights the side effects, tolerability issues,… Continue reading [Comment] Targeting auto-antibodies for CIDP: hope and questions

[Comment] Amyloid removal and the appearance of brain volume loss

AI SummaryThe article discusses the challenges in developing disease-modifying therapies for Alzheimer’s disease and highlights the promising results of new anti-amyloid β immunotherapies. These therapies have shown modest improvements in disease progression and have gained regulatory approval. However, there is a surprising observation of excess brain atrophy associated with these treatments. This finding may have… Continue reading [Comment] Amyloid removal and the appearance of brain volume loss

[Comment] Diagnosis of multiple sclerosis: challenges and opportunities

AI SummaryThe text discusses the challenges faced in diagnosing multiple sclerosis, especially in regions with limited healthcare resources like low-income and middle-income countries. It highlights the lack of data on multiple sclerosis-related morbidity and mortality in certain regions, making it difficult to predict the global burden of the disease. The article suggests that improving access… Continue reading [Comment] Diagnosis of multiple sclerosis: challenges and opportunities

AF Ablation Works…But: SHAM PVI

AI SummaryThis article discusses the results of the first sham-controlled trial of atrial fibrillation ablation with pulmonary vein isolation, showing a placebo-resistant benefit. However, the author notes that questions still remain about how this treatment works.The first sham-controlled trial of atrial fibrillation ablation with pulmonary vein isolation shows a placebo-resistant benefit, but questions remain about… Continue reading AF Ablation Works…But: SHAM PVI

Experience Dependence of Alpha Rhythms and Neural Dynamics in the Mouse Visual Cortex

AI SummaryThis study explored how early-life experiences impact cortical dynamics in the visual cortex of adult, head-fixed mice. Two forms of blindness were induced before eye opening and were shown to have unique effects on network behavior. Enucleation led to changes in low-frequency synchronization during movement, resembling human alpha oscillations, while eyelid suture altered neural… Continue reading Experience Dependence of Alpha Rhythms and Neural Dynamics in the Mouse Visual Cortex

Neural Activity Differentiates Novel and Learned Event Boundaries

AI SummaryThis article discusses how neural activity differentiates between novel and learned event boundaries. The study involved exposing participants to a sequence of images and then testing their ability to segment another sequence based on learned transitions between communities and novel transitions. The results showed that participants could segment experiences into events based on both… Continue reading Neural Activity Differentiates Novel and Learned Event Boundaries