A research team has identified a crucial link between a gene mutation and immune system signaling in canine hemangiosarcoma, an aggressive cancer common in dogs. The discovery could lead to better treatments for both dogs and humans with similar cancers.
Category: Immunology
Researchers identify key protein to potentially halt autoimmune diseases and allergies
Researchers identified a key protein as a potential therapeutic target for stopping the body’s immune system from mistakenly attacking itself, offering new hope for treating autoimmune diseases and allergies. The researchers proved if they therapeutically target the protein Apex1 with chemical inhibitors to either turn it off or remove it completely, then this could be… Continue reading Researchers identify key protein to potentially halt autoimmune diseases and allergies
Study finds potential target for stopping immune system attacks in autoimmune diseases
Houston Methodist researchers have identified a key protein as a potential therapeutic target for stopping the body’s immune system from mistakenly attacking itself, offering new hope for treating autoimmune diseases and allergies. The paper titled “Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models,” appeared recently in the Journal… Continue reading Study finds potential target for stopping immune system attacks in autoimmune diseases
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Abstract Maturation of conventional dendritic cells (cDCs) is crucial for maintaining tolerogenic safeguards against auto-immunity and for promoting immunogenic responses to pathogens and cancer. The subcellular mechanism for cDC maturation remains poorly defined. We show that cDCs mature by leveraging an internal reservoir of cholesterol (harnessed from extracellular cell debris and generated by de novo… Continue reading Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Breakthrough study maps critical structure of Nipah virus polymerase
Scientists at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a critical component of the Nipah virus, a highly lethal bat-borne pathogen that has caused outbreaks in humans almost every year since it was identified in 1999. The advance, described Jan. 20 in Cell, brings scientists a step closer… Continue reading Breakthrough study maps critical structure of Nipah virus polymerase
Study reveals how children’s immune systems react to cancer
Researchers at Karolinska Institutet and the Astrid Lindgren Children’s Hospital in Sweden have determined how children’s immune systems react to different kinds of cancer depending on their age. The study, which is published in the journal Cell, reveals significant differences between the immune response of children and adults, and has the potential to lead to… Continue reading Study reveals how children’s immune systems react to cancer
Inflammation may explain stomach problems in psoriasis sufferers
People with the skin condition psoriasis often have invisible inflammation in the small intestine with an increased propensity for ‘leaky gut’, according to new research. These changes in the gut could explain why psoriasis sufferers often have gastrointestinal problems and are more prone to developing Crohn’s disease.
New study paves way for immunotherapies tailored for childhood cancers
Researchers have determined how children’s immune systems react to different kinds of cancer depending on their age. The study reveals significant differences between the immune response of children and adults, and has the potential to lead to new tailored treatments for children with cancer.
Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
Abstract Viral variant and host vaccination status impact infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yet how these factors shift cellular responses in the human nasal mucosa remains uncharacterized. We performed single-cell RNA sequencing (scRNA-seq) on nasopharyngeal swabs from vaccinated and unvaccinated adults with acute Delta and Omicron SARS-CoV-2 infections and integrated with… Continue reading Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2