Category: Immunology
Molecular allergy diagnosis enabling personalized medicine.
Targeting alarmins in asthma- From the bench to the clinic
2024: The year in review
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Robles-Vera et al. unveil the capacity of gut microbiota translocation, particularly Enterococcus faecalis, to mediate a Mincle-dependent induction of trained immunity in myeloid bone marrow progenitors. This can be protective against subsequent infection but may also mediate a detrimental inflammatory response linked to colitis.
Study of deadly dog cancer reveals new clues for improved treatment
A research team has identified a crucial link between a gene mutation and immune system signaling in canine hemangiosarcoma, an aggressive cancer common in dogs. The discovery could lead to better treatments for both dogs and humans with similar cancers.
Researchers identify key protein to potentially halt autoimmune diseases and allergies
Researchers identified a key protein as a potential therapeutic target for stopping the body’s immune system from mistakenly attacking itself, offering new hope for treating autoimmune diseases and allergies. The researchers proved if they therapeutically target the protein Apex1 with chemical inhibitors to either turn it off or remove it completely, then this could be… Continue reading Researchers identify key protein to potentially halt autoimmune diseases and allergies
Study finds potential target for stopping immune system attacks in autoimmune diseases
Houston Methodist researchers have identified a key protein as a potential therapeutic target for stopping the body’s immune system from mistakenly attacking itself, offering new hope for treating autoimmune diseases and allergies. The paper titled “Apex1 safeguards genomic stability to ensure a cytopathic T cell fate in autoimmune disease models,” appeared recently in the Journal… Continue reading Study finds potential target for stopping immune system attacks in autoimmune diseases
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Abstract Maturation of conventional dendritic cells (cDCs) is crucial for maintaining tolerogenic safeguards against auto-immunity and for promoting immunogenic responses to pathogens and cancer. The subcellular mechanism for cDC maturation remains poorly defined. We show that cDCs mature by leveraging an internal reservoir of cholesterol (harnessed from extracellular cell debris and generated by de novo… Continue reading Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Breakthrough study maps critical structure of Nipah virus polymerase
Scientists at Harvard Medical School and Boston University Chobanian & Avedisian School of Medicine have mapped a critical component of the Nipah virus, a highly lethal bat-borne pathogen that has caused outbreaks in humans almost every year since it was identified in 1999. The advance, described Jan. 20 in Cell, brings scientists a step closer… Continue reading Breakthrough study maps critical structure of Nipah virus polymerase