Category: Immunology

Through epitope cross-reactivity, molecular mimicry between microbial and host antigens may help with autoimmunity as well as tumor protection. According to a recent study published in the journal Science, those cross-reactive epitopes may be caused by viruses that infect endogenous microbial species. & nbsp, In this study, the authors made the unexpected finding that in… Continue reading A specific bacteria-infecting virus, bacteriophage, found in gut microflora, augments anti-tumor T cell immunity

The most recent paper that asserts they can do it is presented here. It appeared in the journal Science Translational Medicine. This journal is run by Science and is fairly reputable. This research team even established a new biotech company to commercialize their strategy because they are so certain of their data. I’m going to… Continue reading Is it possible to engineer Foxp3+ Tregs from primary T cells?

The most crucial part of the immune system is made up of Foxp3 + regulatory T cells( Tregs ). No other cell population, taken individually, plays such a crucial part in the immune system’s proper operation. Trepts are known to prevent an unsuitable immune response against commensal microbiota, nonself pathogens, and self-antigens. & nbsp, I… Continue reading Do Tregs inhibit or promote allergic responses? How to avoid data misinterpretation

Papers published in the journal Science are required to go through a thorough, high-level vetting procedure. But making mistakes is human. Because they are both human, reviewers and editors make mistakes frequently, much to the chagrin of scientists and the delight of postdocs participating in journal clubs. In addition, & nbsp, Here is an illustration… Continue reading Microbiota-derived peptide and autoimmune heart inflammation: a tale of missing data

Three possible outcomes for the development of T cells in the thymus have been discovered so far: to become Foxp3 + Treg, to be deleted, or to develop into naiveT cells. The presence of particular epitopes is necessary for both deletion and the Treg path. It is unclear how a specific T cell chooses between… Continue reading Tracking deletion of autoreactive clones versus Treg generation for thymically expressed epitopes

The majority of tumors have mutant epitopes that T cells could find. In accordance with the current paradigm, CD4 + T cells aid in the attack of tumors by CD8 + T cells. Due to the fact that CD8 + T cells typically express class I molecules but not class II molecules, & nbsp’s primary… Continue reading Tumor elimination requires simultaneous expression of both class I and II neo-epitopes

The most significant cell type in the immune system are regulatory T cells, also known as Tregs, which express the transcription factor Foxp3. Without them, the immune system as a whole malfunctions. As a result, the body simply passes away quickly. The TCR signaling and IL-2 are necessary for the Tregs to develop in the… Continue reading The auto-reactive CD4+ T cells provide IL-2 to proto-Tregs in the thymus

A very thought-provoking study from Mark Davis’ lab was recently published in the journal Nature. In it, the authors describe the existence of a specialized population of CD8 + T cells that prevented autoimmune brain inflammation( EAE ) in mice — a human multiple sclerosis laboratory model. Let’s examine the findings of the study. Both… Continue reading Do regulatory CD8+ T cells control autoreactive CD4+ T cells in the mouse model of human MS?