Category: Immunology
New study links intestinal protein to food allergy development
When is food simply nourishing and enjoyable, and when does it provoke an allergic reaction? The answer appears to lie in the balance of microbes that live in our intestine – and a specific protein secreted by intestinal goblet cells that influences that balance. Excess amounts of this protein, RELMb, changes the profile of intestinal… Continue reading New study links intestinal protein to food allergy development
Researchers discover how location affects immune cells’ role in fighting disease
The human immune system is like an army of specialized soldiers (immune cells) each with a unique role to play in fighting disease. In a new study published in Nature, led by scientists at the Allen Institute, La Jolla Institute for Immunology, and UC San Diego, researchers reveal how cells known as tissue-resident memory CD8… Continue reading Researchers discover how location affects immune cells’ role in fighting disease
Allergen-induced activation of epithelial P2Y2 receptors promotes ATP exocytosis and type 2 immunity in airways
Longitudinal integrated proteomic and metabolomic skin changes in atopic dermatitis patients treated with dupilumab
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair
scRNA-seq has uncovered ontogenically distinct hepatic macrophage populations, but their functions remain unclear. Here, De Ponti et al. identify recruited LAMs and resident LAM-like KCs in multiple liver injury models and reveal that TREM2 expression on at least one of these is necessary to clear damaged cells, mediating tissue repair.
T cells rise up to fight infections in the gut
Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation — and relocation — as they fight infections in the small intestine.
PET probe images inflammation with high sensitivity and selectivity
Researchers have developed a breakthrough method to detect inflammation in the body using positron emission tomography (PET) imaging. This innovative probe targets CD45, a marker abundantly expressed on all immune cells but absent from other cell types.
MASP1 modulation as a novel therapeutic target in severe pediatric pertussis: insights from a multi-omics approach
Infection and Immunity, Ahead of Print.
TSST-1 promotes colonization of Staphylococcus aureus within the vaginal tract by activation of CD8+ T cells
Infection and Immunity, Ahead of Print.