Study Shows Increased Bronchitis Risk and Shortness of Breath for Young People Who Vape

A recent study found that young vapers are at increased risk of bronchitis symptoms and shortness of breath. The researchers defined bronchitis symptoms as a daily cough for three consecutive months, a bronchitis diagnosis in the previous 12 months, and congestion or phlegm without a cold. This study explored the potential impact of concurrent cigarette… Continue reading Study Shows Increased Bronchitis Risk and Shortness of Breath for Young People Who Vape

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Categorized as Immunology

New biomarker could help identify people at risk for vascular dementia

Dementia is a group of brain diseases that share similar symptoms, such as memory, language, orientation, and behavioral issues. Vascular dementia generally develops in the elderly, affecting between 1% and 4% of people over the age of 65, according to Alzheimer’s Switzerland. It is caused by vascular lesions that disrupt the blood supply to the… Continue reading New biomarker could help identify people at risk for vascular dementia

Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma

Abstract Glioblastoma (GBM) tumors consist of multiple cell populations, including self-renewing glioblastoma stem cells (GSCs) and immunosuppressive microglia. Here we identified Kunitz-type protease inhibitor TFPI2 as a critical factor connecting these cell populations and their associated GBM hallmarks of stemness and immunosuppression. TFPI2 promotes GSC self-renewal and tumor growth via activation of the c-Jun N-terminal… Continue reading Kunitz-type protease inhibitor TFPI2 remodels stemness and immunosuppressive tumor microenvironment in glioblastoma

TFPI2 is key for cancer stem cell–microglia symbiosis in glioblastoma

Glioblastoma is a devastating primary brain tumor consisting of multiple cell populations. We identified TFPI2 as the crucial effector of the symbiotic interaction between glioblastoma stem cells and microglia. Blockade of this symbiosis inhibited tumor growth and synergized with an immune checkpoint inhibitor in mouse models of glioblastoma. This is a preview of subscription content,… Continue reading TFPI2 is key for cancer stem cell–microglia symbiosis in glioblastoma

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Categorized as Immunology

Michigan researchers receive $26 million NIH grant to study environmental impacts on child health

Backed by a $26 million federal grant, researchers at three Michigan universities, a leading health care system, and a state agency will continue a long-term study of how exposure to environmental factors during pregnancy and early childhood can impact health for a lifetime. The funding from the National Institutes of Health, or NIH, is for… Continue reading Michigan researchers receive $26 million NIH grant to study environmental impacts on child health

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Categorized as Immunology

Scientists reclassify 200 rare immune system disorders using network-based approach

Scientists at CeMM, Max Perutz Labs, and St. Anna Children’s Cancer Research Institute in Vienna have achieved a significant advancement in the research of rare immune system disorders. Through a network-based approach, they have reclassified approximately 200 rare diseases. Initial comparisons with clinical data already demonstrate how this can enhance the prediction of treatment efficacy.… Continue reading Scientists reclassify 200 rare immune system disorders using network-based approach

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Categorized as Immunology

Study sheds light on immune cells’ ability to collectively migrate through complex environments

When fighting disease, our immune cells need to reach their target quickly. Researchers at the Institute of Science and Technology Austria (ISTA) now discovered that immune cells actively generate their own guidance system to navigate through complex environments. This challenges earlier notions about these movements. The researchers’ findings, published in the journal Science Immunology, enhance… Continue reading Study sheds light on immune cells’ ability to collectively migrate through complex environments

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Categorized as Immunology

International consortium to study link between RSV infection and chronic respiratory tract diseases

UMC Utrecht will lead an international consortium that will try to answer a key question that’s in the mind of many pediatricians, infectiologists, pulmonologists and other health professionals: “Why are children that had an RSV infection in early childhood at increased risk of developing asthma later in life?” The project – which will run for… Continue reading International consortium to study link between RSV infection and chronic respiratory tract diseases