Using an animal model of multiple sclerosis (MS), researchers have created a four-dimensional brain map that reveals how lesions similar to those seen in human MS form. These findings provide a window into the early disease state and could help identify potential targets for MS treatments and brain tissue repair.
Category: Immunology
Innate immune training aggravates inflammatory bone loss
Researchers have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in experimental models of periodontitis and inflammatory arthritis.
Researchers uncover pathways of bacterial spread in the bloodstream
Bacteremia, or blood poisoning, occurs when bacteria overcome the body’s immune defenses. Bacteremia can worsen into sepsis, a condition that accounts for more than 1 in 3 hospital deaths per year. Yet people are routinely exposed to and fight off bacteria from the environment without this deadly series of events occurring. Scientists are trying to… Continue reading Researchers uncover pathways of bacterial spread in the bloodstream
Nasal spray shows preclinical promise for treating traumatic brain injury
A new study suggests a nasal spray developed to target neuroinflammation could one day be an effective treatment for traumatic brain injury (TBI). By studying the effects of the nasal anti-CD3 in a mouse model of TBI, researchers found the spray could reduce damage to the central nervous system and behavioral deficits, suggesting a potential… Continue reading Nasal spray shows preclinical promise for treating traumatic brain injury
Breakthrough study discovers genetic mutation could be basis for novel treatment of rheumatoid arthritis
Research reveals how a specific mutation in a protein called TRAF1 can shut down an overactive immune response, dramatically reducing inflammation in mice. This discovery could pave the way for a new class of drugs to treat rheumatoid arthritis, according to one of the authors. Using gene-editing technology, the researchers identified a critical mutation of… Continue reading Breakthrough study discovers genetic mutation could be basis for novel treatment of rheumatoid arthritis
Study highlights increase in VZV-induced CNS infections and dementia risk
Researchers from Fujita Health University, Japan, observed a rise in adult central nervous system (CNS) infections, primarily aseptic meningitis caused by the varicella zoster virus (VZV), post-2019. The researchers highlighted the potential of zoster vaccination to reduce CNS infections. Meanwhile, CNS infection by herpesviruses, including VZV, may contribute to the progression of dementia. Furthermore, the… Continue reading Study highlights increase in VZV-induced CNS infections and dementia risk
Nasal spray may offer new hope for traumatic brain injury patients
A new study led by researchers at Mass General Brigham suggests a nasal spray developed to target neuroinflammation could one day be an effective treatment for traumatic brain injury (TBI). By studying the effects of the nasal anti-CD3 in a mouse model of TBI, researchers found the spray could reduce damage to the central nervous… Continue reading Nasal spray may offer new hope for traumatic brain injury patients
A call for the United States to continue investing in science
Infection and Immunity, Ahead of Print.
A call for healing and unity
Infection and Immunity, Ahead of Print.