A research team has investigated a new combination therapy against cancer. This therapy employs systemic administration of the tissue hormone interferon-I combined with local application of Imiquimod. This combination showed promising results in topically accessible tumors like melanoma and breast cancer models: The therapy led to the death of tumor cells at the treated sites… Continue reading New combination immunotherapy for melanoma and breast cancer
Category: Immunology
The interplay between Acinetobacter baumannii ZigA and SltB promotes zinc homeostasis and cell envelope integrity
Infection and Immunity, Ahead of Print.
Complement C3 of tumor-derived extracellular vesicles promotes metastasis of RCC via recruitment of immunosuppressive myeloid cells
The LIM-domain-only protein LMO2 and its binding partner LDB1 are differentially required for class switch recombination
New study links intestinal protein to food allergy development
When is food simply nourishing and enjoyable, and when does it provoke an allergic reaction? The answer appears to lie in the balance of microbes that live in our intestine – and a specific protein secreted by intestinal goblet cells that influences that balance. Excess amounts of this protein, RELMb, changes the profile of intestinal… Continue reading New study links intestinal protein to food allergy development
Researchers discover how location affects immune cells’ role in fighting disease
The human immune system is like an army of specialized soldiers (immune cells) each with a unique role to play in fighting disease. In a new study published in Nature, led by scientists at the Allen Institute, La Jolla Institute for Immunology, and UC San Diego, researchers reveal how cells known as tissue-resident memory CD8… Continue reading Researchers discover how location affects immune cells’ role in fighting disease
Allergen-induced activation of epithelial P2Y2 receptors promotes ATP exocytosis and type 2 immunity in airways
Longitudinal integrated proteomic and metabolomic skin changes in atopic dermatitis patients treated with dupilumab
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair
scRNA-seq has uncovered ontogenically distinct hepatic macrophage populations, but their functions remain unclear. Here, De Ponti et al. identify recruited LAMs and resident LAM-like KCs in multiple liver injury models and reveal that TREM2 expression on at least one of these is necessary to clear damaged cells, mediating tissue repair.
T cells rise up to fight infections in the gut
Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation — and relocation — as they fight infections in the small intestine.