1. When B. theta-specific T cells are transferred into# antibiotic-treated mice (# RAG1 – KO ), they become# Foxp3 + # Tregs as well as effector cells. It’s unclear if donor tg T cells were also present on the RAG1 – KO background. Host mice maintain their health. pic. twitter.com / TD0pnnxgARDavid Usharauli(@ 3DiMMUNE )… Continue reading An antigen from gut commensal Bacteroides thetaiotaomicron (B. theta) is recognized by Foxp3+ Tregs
Category: Immunology
11-strain consortium from human faecal microbiota drives IFN-gamma production in CD8 T cells
11 microbial species from the human faecal # microbiota were found in a new study @ nature by Japanese scientists( Konda, Atarashi, & amp, etc. ) that increased# IFN – gamma + # CD8 T cells protective against # infection and # tumors.— David Usharauli on January 24, 2019 (@ 3DiMMUNE ) 2. 2. Even… Continue reading 11-strain consortium from human faecal microbiota drives IFN-gamma production in CD8 T cells
Two non-overlapping precursors generate Foxp3+ regulatory T cells in the thymus
The # Treg differentiation potential of # CD25 + and Foxp3( low ) precursors in the ## thymus was compared in a recent study published in @ NatImmunol. http :// t.co / rIFWqybNnmpic.twitter.com / 9ibTGBeHF9— David Usharauli on January 22, 2019 (@ 3DiMMUNE ) 2. 2. Reliance on # IL4 # signaling to generate Tregs… Continue reading Two non-overlapping precursors generate Foxp3+ regulatory T cells in the thymus
Foxp3+ Tregs suppress other T cells by stripping DCs of specific antigen/MHC complexes
Ag-specific or not Ag-specific, that is [maybe was] question for #Foxp3+ Tregs mechanism of action. New paper in @NatImmunol from #Shevach‘s lab @NIH says definitely antigen-specific. Lets dive in. BTW, ~20 years ago his lab developed assays that showed it was non-specific 🤫 — David Usharauli (@3DiMMUNE) January 16, 2019 Now his lab made U-turn… Continue reading Foxp3+ Tregs suppress other T cells by stripping DCs of specific antigen/MHC complexes
Tumor infiltrating Foxp3+ Tregs recognize synthesized but not naturally available cancer neoantigens
Steven Rosenberg and colleagues from @ NIH ask why # Tregs build up in tumor tissues and if it has anything to do with # cancer # antigen recognition in a recent paper published in @ SciImmunology. But how can # Foxp3 + Tregs in humans be studied? There isn’t a trustworthy surface marker yet.David… Continue reading Tumor infiltrating Foxp3+ Tregs recognize synthesized but not naturally available cancer neoantigens