Category: Immunology

In a rat model of human # MultipleSclerosis, synuclein-specific CD4 + T cells invade # brain grey matter and produce an array of MS-like symptoms. It’s interesting to note that suppl materials contained the most useful distilled data points. https: // t # immunology # autoimmunedisease co / NbIt5ijxuR— March 5, 2019 David Usharauli(@ 3DiMMUNE… Continue reading β-synuclein specific CD4+ T cells invade brain grey matter to cause array of MS-like symptoms

According to a recent study from Bacher / Scheffold lab, gut commensal pathobiont # Candida # albicans via # crossreactivity has expanded the IL – 17 + T cell response to airborne # fungus like # Aspergillus fumigatus found in people with # asthma, # COPD, and CF.— David Usharauli on February 23, 2019 (@… Continue reading IL-17 response to airborne fungi are driven by gut commensal pathobiont C. albicans

The study is about origin of B1vs.B2 cells. B1 cells are innate-like B cell lineage that reside in peritoneal & pleural cavities and express restricted BCRs specific for conserved molecules such as phosphatidylcholine. B2 cells are conventional B cells expressing diverse of BCR. — David Usharauli (@3DiMMUNE) February 16, 2019 1. This is a model… Continue reading No going back: conventional B cells (B2) could trans-differentiate into innate-like B cells (B1) but not vice versa

1. When B. theta-specific T cells are transferred into# antibiotic-treated mice (# RAG1 – KO ), they become# Foxp3 + # Tregs as well as effector cells. It’s unclear if donor tg T cells were also present on the RAG1 – KO background. Host mice maintain their health. pic. twitter.com / TD0pnnxgARDavid Usharauli(@ 3DiMMUNE )… Continue reading An antigen from gut commensal Bacteroides thetaiotaomicron (B. theta) is recognized by Foxp3+ Tregs

11 microbial species from the human faecal # microbiota were found in a new study @ nature by Japanese scientists( Konda, Atarashi, & amp, etc. ) that increased# IFN – gamma + # CD8 T cells protective against # infection and # tumors.— David Usharauli on January 24, 2019 (@ 3DiMMUNE ) 2. 2. Even… Continue reading 11-strain consortium from human faecal microbiota drives IFN-gamma production in CD8 T cells

The # Treg differentiation potential of # CD25 + and Foxp3( low ) precursors in the ## thymus was compared in a recent study published in @ NatImmunol. http :// t.co / rIFWqybNnmpic.twitter.com / 9ibTGBeHF9— David Usharauli on January 22, 2019 (@ 3DiMMUNE ) 2. 2. Reliance on # IL4 # signaling to generate Tregs… Continue reading Two non-overlapping precursors generate Foxp3+ regulatory T cells in the thymus

Ag-specific or not Ag-specific, that is [maybe was] question for #Foxp3+ Tregs mechanism of action. New paper in @NatImmunol from #Shevach‘s lab @NIH says definitely antigen-specific. Lets dive in. BTW, ~20 years ago his lab developed assays that showed it was non-specific 🤫 — David Usharauli (@3DiMMUNE) January 16, 2019 Now his lab made U-turn… Continue reading Foxp3+ Tregs suppress other T cells by stripping DCs of specific antigen/MHC complexes

Steven Rosenberg and colleagues from @ NIH ask why # Tregs build up in tumor tissues and if it has anything to do with # cancer # antigen recognition in a recent paper published in @ SciImmunology. But how can # Foxp3 + Tregs in humans be studied? There isn’t a trustworthy surface marker yet.David… Continue reading Tumor infiltrating Foxp3+ Tregs recognize synthesized but not naturally available cancer neoantigens