Category: Immunology

The majority of tumors have mutant epitopes that T cells could find. In accordance with the current paradigm, CD4 + T cells aid in the attack of tumors by CD8 + T cells. Due to the fact that CD8 + T cells typically express class I molecules but not class II molecules, & nbsp’s primary… Continue reading Tumor elimination requires simultaneous expression of both class I and II neo-epitopes

The most significant cell type in the immune system are regulatory T cells, also known as Tregs, which express the transcription factor Foxp3. Without them, the immune system as a whole malfunctions. As a result, the body simply passes away quickly. The TCR signaling and IL-2 are necessary for the Tregs to develop in the… Continue reading The auto-reactive CD4+ T cells provide IL-2 to proto-Tregs in the thymus

A very thought-provoking study from Mark Davis’ lab was recently published in the journal Nature. In it, the authors describe the existence of a specialized population of CD8 + T cells that prevented autoimmune brain inflammation( EAE ) in mice — a human multiple sclerosis laboratory model. Let’s examine the findings of the study. Both… Continue reading Do regulatory CD8+ T cells control autoreactive CD4+ T cells in the mouse model of human MS?

The mechanism of type 1 diabetes ( T1D ) has been investigated using the mouse strain NOD. Although it is unclear how islet-specific T cells become activated, these mice spontaneously develop autoimmune diabetes. TCR transgenic mice, BDC2.5XNOD, have been used to monitor the fate of autoimmune T cells. These mice have a large number of… Continue reading Pathological changes in the gut could initiate autoimmune diabetes microbiota-specific manner

The body’s microbiota now unquestionably plays a significant role in preventing allergies, including food allergies. However, it is less clear exactly how the microbiota does it. According to a recent study in mice that was published in Nature Medicine, the RORt + Tregs subset of the FOXP3 + gene family uses the adaptor MyD88 to… Continue reading Select microbiota species provides protection against food allergy via RORγt+ Tregs

Without a doubt, the most significant immune cell type is the thymus-derived Foxp3 + Tregs. Surprisingly, not much has been done to determine the specificity of their antigen. The fact that most scientists believed Tregs inhibited unwanted T cell responses antigen in a non-specific way is one reason for this lack of interest in studying… Continue reading A neonatal temporal window for thymic epitope-specific Foxp3+ Treg formation

Along with autoimmune diseases, the prevalence of allergies to food antigens is rising globally. Many people think that changes in the microbiota’s composition brought on by the effects of processed foods and the environment are to blame. However, we are still unsure of the precise mechanism by which the microbiota prevents immune dysregulation, which is… Continue reading Allergy: A newborn’s microbiota prevents hyper IgE antibody response to certain food antigens

An excellent study by Japanese researchers published in @ sciencemagazine demonstrates how the surface of the same DC is sequestered by the co-stimulatory molecule # CD80 and promotes # Tcell # activation. Immunology, tolerance, and immunotherapyhttps: // t. co / RcArRXV9XTDavid Usharauli(@ 3DiMMUNE ) on April 23, 2019. 1. The authors first noticed that, in… Continue reading CD80 sequesters PDL1 on DC’s surface and promotes T cell activation

1. The authors used mice( genes believed to have been changed in # Crohns ) that were doubly deficient in Nod2 / Cybb /] NADPH oxidase ( DKO ). These DKO pups develop spontaneous gut # inflammation after weaning( 3 weeks after birth ) when they are fostered with Taconic dams but not Jax Dams.… Continue reading Crohn’s disease-like phenotype could be initiated by one gut microbe in genetically susceptible mice

According to a recent study published in @ Nature, gut # ILC3( type 3 innate lymphoid cells ) produce IL-2 for # FOXP3 + Tregs. Is it pertinent? Let’s talk about it. https: // t # Immunology # tolerance # microbiota co / iziPJb09ZyDavid Usharauli(@ 3DiMMUNE ) on April 3, 2019. 2. 2. It’s interesting… Continue reading Innate help to Tregs in the gut