Reference: Bijker, E.M., Rösler, B., Hoppenreijs, E. et al. Functional Asplenia and Specific Polysaccharide Antibody Deficiency in a Girl with SAVI. J Clin Immunol (2020). Continue Reading
Category: Immunology
PID and role of Next-generation sequencing in India
Reference: Arunachalam, A.K., Maddali, M., Aboobacker, F.N. et al. Primary Immunodeficiencies in India: Molecular Diagnosis and the Role of Next-Generation Sequencing. J Clin Immunol (2020). https://doi.org/10.1007/s10875-020-00923-2 Continue Reading
October Update for Inborn Errors of Immunity
40 PUBMED indexed articles were published in the month of October 2020 on PID. New Inborn Error of Immunity Beck et al report a novel auto-inflammatory syndrome associated somatic mutations in UBA1 presenting in adulthood with a severe phenotype COVID-19 and PID Mantravadi et al report the recovery of X-CGD who had T cell lymphopenia… Continue reading October Update for Inborn Errors of Immunity
The gamut of clinical manifestations in RALD
Reference: Neven Q, Boulanger C, Bruwier A, de Ville de Goyet M, Meyts I, Moens L, Van Damme A, Brichard B. Clinical Spectrum of Ras-Associated Autoimmune Leukoproliferative Disorder (RALD). J Clin Immunol. 2020 Oct 4. Continue Reading
September Update for Inborn Errors of Immunity
38 PUBMED indexed articles were published in the month of September 2020. COVID-19 and PID Zang et al report defects in TLR3- and IRF7-dependent type I IFN immunity that may predispose patients to life-threatening COVID-19 pneumonia Bastard et al report auto-antibodies against IFN-ω and IFN-α that neutralize the action of type I IFNs against Sars-Cov2… Continue reading September Update for Inborn Errors of Immunity
IPEX and IPEX-like Syndromes
Reference: Jamee M, Zaki-Dizaji M, Lo B, Abolhassani H, Aghamahdi F, Mosavian M, Nademi Z, Mohammadi H, Jadidi-Niaragh F, Rojas M, Anaya JM, Azizi G, Clinical, immunological, and genetic features in patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) and IPEX-like Syndrome, The Journal of Allergy and Clinical Immunology: In Practice (2020) Continue Reading
A specific bacteria-infecting virus, bacteriophage, found in gut microflora, augments anti-tumor T cell immunity
Through epitope cross-reactivity, molecular mimicry between microbial and host antigens may help with autoimmunity as well as tumor protection. According to a recent study published in the journal Science, those cross-reactive epitopes may be caused by viruses that infect endogenous microbial species. & nbsp, In this study, the authors made the unexpected finding that in… Continue reading A specific bacteria-infecting virus, bacteriophage, found in gut microflora, augments anti-tumor T cell immunity
Is it possible to engineer Foxp3+ Tregs from primary T cells?
The most recent paper that asserts they can do it is presented here. It appeared in the journal Science Translational Medicine. This journal is run by Science and is fairly reputable. This research team even established a new biotech company to commercialize their strategy because they are so certain of their data. I’m going to… Continue reading Is it possible to engineer Foxp3+ Tregs from primary T cells?
Do Tregs inhibit or promote allergic responses? How to avoid data misinterpretation
The most crucial part of the immune system is made up of Foxp3 + regulatory T cells( Tregs ). No other cell population, taken individually, plays such a crucial part in the immune system’s proper operation. Trepts are known to prevent an unsuitable immune response against commensal microbiota, nonself pathogens, and self-antigens. & nbsp, I… Continue reading Do Tregs inhibit or promote allergic responses? How to avoid data misinterpretation
Microbiota-derived peptide and autoimmune heart inflammation: a tale of missing data
Papers published in the journal Science are required to go through a thorough, high-level vetting procedure. But making mistakes is human. Because they are both human, reviewers and editors make mistakes frequently, much to the chagrin of scientists and the delight of postdocs participating in journal clubs. In addition, & nbsp, Here is an illustration… Continue reading Microbiota-derived peptide and autoimmune heart inflammation: a tale of missing data