Thought LeadersLiam O’Mahony, Barry Skillington & John MacSharryProf. of Immunology, Cheif Commerical Officer & Research PartnerAtlantia and Clinical Trials Though most people know that their immune system is supported by microbes, the complexity and interrelation between the body’s microbial changes and wider health is something known only to those in the field. With over half the… Continue reading Atlantia Clinical Trials: Investigating the interrelation of microbiology and immunology
Category: Immunology
Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy
Science Immunology, Volume 10, Issue 104, February 2025.
The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis
Science Immunology, Volume 10, Issue 104, February 2025.
Long-term B cell memory emerges at uniform relative rates in the human immune response
Trained immunity may exacerbate inflammatory bone loss disorders
Clinical research has long focused on ways to harness the actions of the immune system. From vaccines to immunotherapies, researchers have used their knowledge of the immune system to develop therapies to treat or prevent diseases from influenza to autoimmune disease and cancer. Now, researchers from Penn’s School of Dental Medicine and international collaborators have investigated the… Continue reading Trained immunity may exacerbate inflammatory bone loss disorders
Cambridge launches program to tackle engineered pandemic risks
Covid-19 showed us how vulnerable the world is to pandemics – but what if the next pandemic were somehow engineered? How would the world respond – and could we stop it happening in the first place? These are some of the questions being addressed by a new initiative launched today at the University of Cambridge,… Continue reading Cambridge launches program to tackle engineered pandemic risks
How our lungs back up the bone marrow to make our blood
Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing. For many years, scientists assumed that blood production took place in the bone marrow. But now, researchers are showing it’s also happening in… Continue reading How our lungs back up the bone marrow to make our blood
EU project aims to combat dangerous viruses with molecular interventions
Targeted molecular interventions in the replication cycle and the immune recognition of viruses are intended to prevent viral entry into cells and virus replication. That is the goal of an international research project in which scientists work on new approaches to combating highly dangerous viral diseases such as yellow fever or Lassa fever. Coordinating the… Continue reading EU project aims to combat dangerous viruses with molecular interventions
The rewired immune microenvironment in leukemia
Abstract Leukemias are a class of human cancers that originate from hematopoietic progenitors and are characterized by extensive remodeling of the immune microenvironment. Leukemic cells, on transformation, acquire the ability to evade immune recognition but, despite undergoing genetic and epigenetic changes, retain their characteristic immature immune signature. For this and other reasons, leukemias are often… Continue reading The rewired immune microenvironment in leukemia
Protective SARS-CoV-2-specific T cells take up residence
Virus-specific T cells within the mucosa mediate local defense and establish tissue-resident memory. Strong and functional mucosal SARS-CoV-2-specific responses associate with viral clearance and their effective induction is an important aspiration for vaccine regimens. This is a preview of subscription content, access via your institution Access options Access through your institution Change institution Buy or… Continue reading Protective SARS-CoV-2-specific T cells take up residence