A natural compound derived from gut-friendly bacteria significantly slows the progression of vitiligo and may restore pigmentation, reports a new Northwestern University pre-clinical study in mice. The findings could offer hope to millions affected by the autoimmune disease, which causes visible patches of skin discoloration and carries profound emotional and physical consequences. The results in our… Continue reading Microbial compound offers hope for vitiligo treatment
Category: Immunology
T cells grown with new technique offer better cancer defense
Researchers from the University of Pittsburgh have developed a new way to grow T cells in the lab that enables them to live longer and better destroy cancer cells in a mouse model of melanoma compared to those grown in traditional growth media. The findings, published recently in Cell Metabolism, have the potential to greatly… Continue reading T cells grown with new technique offer better cancer defense
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation
Abstract γδ T cells producing either interleukin-17A (γδ17 cells) or interferon-γ (γδIFN cells) are generated in the mouse thymus, but the molecular regulators of their peripheral functions are not fully characterized. Here we established an Il17a-GFP:Ifng-YFP double-reporter mouse strain to analyze at unprecedented depth the transcriptomes of pure γδ17 cell versus γδIFN cell populations from… Continue reading Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation
Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
Abstract A comprehensive understanding of the evolution of the immune landscape in humans across the entire lifespan at single-cell transcriptional and protein levels, during development, maturation and senescence is currently lacking. We recruited a total of 220 healthy volunteers from the Shanghai Pudong Cohort (NCT05206643), spanning 13 age groups from 0 to over 90 years, and… Continue reading Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
Single-cell profiling of the immune landscape across the human lifespan
Using a combination of single-cell RNA sequencing, T cell and B cell receptor sequencing, and mass cytometry analyses, we characterized the dynamics of peripheral immune cells across the human lifespan. Based on this resource, we present a single-cell immune aging clock to assess an individual’s immune status across different life stages. This is a preview… Continue reading Single-cell profiling of the immune landscape across the human lifespan
Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa
Cell-type-specific SARS-CoV-2-induced responses in nasal mucosa differ largely between ancestral, Delta and Omicron cases, including the association with severe disease and the cellular and immunological effects of prior vaccination. This is a preview of subscription content, access via your institution Access options Access through your institution Change institution Buy or subscribe /* style specs start… Continue reading Variant-specific local tissue response to SARS-CoV-2 in the nasal mucosa
The role of mitochondrial DNA copy number in asthma: Agent or bystander?
New clues to the mechanism behind food tolerance and allergies
Study reveals how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of both food allergies and intestinal diseases.
BEND lipids revolutionize mRNA delivery and gene-editing
Every time a shuttle docks with the International Space Station (ISS), a delicate dance unfolds between the shuttle’s docking system and its counterpart on the station. Thanks to international standards, these mechanisms are universally compatible, ensuring astronauts and cargo can safely and seamlessly enter the station. A similar challenge arises at the microscopic level when… Continue reading BEND lipids revolutionize mRNA delivery and gene-editing
HMB supplement trial explores new treatment for chronic liver disease
A dietary supplement used to build muscle – or prevent muscle loss as a result of aging or illness – is to be trialed as a potential treatment for chronic liver disease. Β-hydroxy β-methylbutyrate, otherwise known as HMB, is used predominantly to build muscle bulk and function but previous studies have demonstrated it can have… Continue reading HMB supplement trial explores new treatment for chronic liver disease