Category: Immunology
The complexity of immune evasion mechanisms throughout the metastatic cascade
AI SummaryThis article discusses the immune evasion mechanisms used by cancer cells throughout the metastatic cascade. It explores how tumor cells adapt to survive in different environments encountered during metastasis, affecting organotropism. The interaction between tumor cells and the immune system is analyzed, emphasizing the creation of an immunosuppressive environment that promotes aggressive metastatic tumors.… Continue reading The complexity of immune evasion mechanisms throughout the metastatic cascade
NIH funds new research to combat emerging viruses
AI SummaryThe Albert Einstein College of Medicine has received funding from the NIH for a five-year project to develop vaccines and antibody-based therapies against emerging viruses. The project aims to build on lessons learned from COVID-19 by creating a base of critical knowledge about groups of similar viruses, allowing for the rapid development of specific… Continue reading NIH funds new research to combat emerging viruses
New insight into the causes of autoimmune diseases
AI SummaryThis article discusses a recent study that provides new insight into the causes of autoimmune diseases. Researchers have discovered that the body’s own proteins with unusual structure can trigger immune cells to attack its own tissues, leading to autoimmunity. The study found that when the MHC-II is missing a crucial piece called the invariant… Continue reading New insight into the causes of autoimmune diseases
Evolution of vaccine adjuvants from empirical discovery to rational design
AI Summarythe evolution towards rational design emphasizes a multifaceted approach that considers both the innate and adaptive immune response, as well as the structural and functional components of adjuvants. This intersection between immunology and medicinal chemistry allows for the optimization of adjuvants to enhance vaccine efficacy and safety. The utilization of advanced techniques and methodologies… Continue reading Evolution of vaccine adjuvants from empirical discovery to rational design
Study reveals how SARS-CoV-2 triggers diabetes by destroying pancreatic cells
AI SummaryThis article discusses a study conducted by researchers from Weill Cornell Medicine that uncovered how SARS-CoV-2 triggers new cases of diabetes and worsens complications in individuals who already have it. The team found that exposure to the virus activates immune cells that destroy pancreatic beta cells responsible for insulin production. The study was published… Continue reading Study reveals how SARS-CoV-2 triggers diabetes by destroying pancreatic cells
Experimental mRNA cancer vaccine shows potential for advanced stage cancer patients in Phase 1 trial
AI SummaryIn a Phase 1 trial, an experimental mRNA cancer vaccine (mRNA-4359) has shown promise in patients with advanced solid cancers such as lung cancer and melanoma. Nineteen patients received between one and nine doses of the vaccine, which created an immune response against cancer. Adverse events were generally mild, including fatigue, injection site pain,… Continue reading Experimental mRNA cancer vaccine shows potential for advanced stage cancer patients in Phase 1 trial
Study finds ‘supercharging’ T cells with mitochondria enhances their antitumor activity
AI SummaryThis article discusses a study where researchers have found that enhancing T cells with extra mitochondria from multipotent stromal cells can improve their antitumor activity. This “supercharging” of T cells could potentially lead to more effective cancer treatments.Investigators have developed a way to ‘supercharge’ T cells by supplying them with extra mitochondria from multipotent… Continue reading Study finds ‘supercharging’ T cells with mitochondria enhances their antitumor activity
Neoself-antigens induce autoimmunity in lupus
AI SummaryThis content discusses how neoself-antigens, abnormal host proteins presented by MHC-II, can induce autoimmunity in lupus. T cells identify these neoself-antigens as non-self antigens, leading to the development of autoimmune responses. Reactivation of Epstein-Barr virus, a risk factor for lupus, increases the presentation of neoself-antigens, potentially linking viral infections to autoimmune diseases.Researchers found that… Continue reading Neoself-antigens induce autoimmunity in lupus
Salt can boost antitumor responses of T cells
AI SummaryThe study explores how sodium (Na+) ions in tumor microenvironments can enhance the activation of cytotoxic T cells, potentially boosting antitumor responses. Previous research indicates that extracellular ions like potassium (K+) impact T-cell functions, but the effects of sodium ions on cytotoxic T cells are less understood. The researchers used ICP-OES to measure ion… Continue reading Salt can boost antitumor responses of T cells