Science Immunology, Volume 10, Issue 103, January 2025.
Category: Immunology
Immune cells orchestrate glucagon production during fasting
When we think about the immune system, we usually associate it with fighting infections. However, a study published in Science by the Champalimaud Foundation reveals a surprising new role. During periods of low energy-such as intermittent fasting or exercise-immune cells step in to regulate blood sugar levels, acting as the “postman” in a previously unknown… Continue reading Immune cells orchestrate glucagon production during fasting
IRE1α–XBP1 moonlighting to restrict leukemia
IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by repressing pro-leukemogenic programs, independent of the unfolded protein response. A treatment strategy for acute myeloid leukemia could involve activation of the IRE1α–XBP1 axis to suppress WNT/β-catenin signaling. This is a preview of subscription content, access via your institution Access options Access through your institution Change institution Buy… Continue reading IRE1α–XBP1 moonlighting to restrict leukemia
Intestinal microbiome metabolites control sepsis outcome
Sepsis results from a dysregulated immune response to infection. A study now shows that gut microbiota-derived metabolites prevent infection-triggered immunopathology by activating the aryl hydrocarbon receptor; pathogens inhibit this protective mechanism. This is a preview of subscription content, access via your institution Access options Access through your institution Change institution Buy or subscribe /* style… Continue reading Intestinal microbiome metabolites control sepsis outcome
Multi-target approach counters tumor growth in several cancers
The tissue adjacent to a tumor behaves differently than areas farther away: The tumor’s cancerous cells influence their surroundings, blocking the body’s immune defenses and creating a sort of haven in which the tumor can grow. Treatments that target some of these pro-tumor actions are effective in a number of cancers, but only for some… Continue reading Multi-target approach counters tumor growth in several cancers
Sophisticated early warning system: How bacteria respond to threats
Researchers have discovered that bacteria can sense threats in advance through a general danger signal. Bacteria detect when nearby cells are dying and proactively form a protective biofilm. Understanding how bacteria communicate and respond to threats is crucial for combating infections.
Protein level predicts immunotherapy response in bowel cancer
Researchers have shown that the amount of a protein called CD74 can indicate which people with bowel cancer may respond best to immunotherapy.
Immune system changes may predict antipsychotic resistance in schizophrenia Scientis…
Researchers from the National Healthcare Group (NHG)’s Institute of Mental Health (IMH) and Agency for Science, Technology and Research (A*STAR) have made strides in understanding the connection between the immune system and resistance to antipsychotic medications in schizophrenia, using changes in immune cell populations to predict potential treatment resistance and initiate the most appropriate treatment… Continue reading Immune system changes may predict antipsychotic resistance in schizophrenia Scientis…
AstraZeneca’s Pioneering Research in Heart Failure and ATTR-CM
Thought LeaderMina MakarSenior Vice President, Global CVRMAstraZeneca NewsMedical spoke with Mina Makar, Senior Vice President of Global CVRM at AstraZeneca, about groundbreaking research in Heart Failure and Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM). Mina shares insights on AstraZeneca’s mission to address unmet needs in cardiovascular care and the future of personalized medicine. Firstly, please introduce yourself and tell us… Continue reading AstraZeneca’s Pioneering Research in Heart Failure and ATTR-CM
Novel method to fight cancer uses ultrasound-guided microbubbles
A new paper by a team of Concordia researchers from the departments of Biology and Physics proposes a novel method of fighting cancer tumors that uses ultrasound-guided microbubbles – a technology already widely used in medical imaging and drug delivery. Writing in the journal Frontiers in Immunology, the researchers describe a process that uses ultrasound to modify the behavior of… Continue reading Novel method to fight cancer uses ultrasound-guided microbubbles