Category: Immunology

Salt can boost antitumor responses of T cells

AI SummaryThe study explores how sodium (Na+) ions in tumor microenvironments can enhance the activation of cytotoxic T cells, potentially boosting antitumor responses. Previous research indicates that extracellular ions like potassium (K+) impact T-cell functions, but the effects of sodium ions on cytotoxic T cells are less understood. The researchers used ICP-OES to measure ion… Continue reading Salt can boost antitumor responses of T cells

Systemic T-cell activation and interferon-γ activity in indeterminate severe hepatitis (iSH) are reminiscent of hemophagocytic lymphohistiocytosis (HLH): Implications for T-cell and interferon-γ directed therapies.

AI SummaryThis article discusses how systemic T-cell activation and interferon-γ activity in indeterminate severe hepatitis (iSH) are similar to hemophagocytic lymphohistiocytosis (HLH). The implications of this include the potential for T-cell and interferon-γ directed therapies for treating iSH. This research highlights the importance of understanding the immune response in severe liver diseases and how it… Continue reading Systemic T-cell activation and interferon-γ activity in indeterminate severe hepatitis (iSH) are reminiscent of hemophagocytic lymphohistiocytosis (HLH): Implications for T-cell and interferon-γ directed therapies.

Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma

Adoptive cell therapy (ACT) using in vitro expanded tumor-infiltrating lymphocytes (TILs) can be curative in melanoma but has inconsistent clinical responses. Chiffelle, Barras, et al. track TIL clonotypes in melanoma patients through ACT therapy and provide insight into the profiles and dynamics of tumor-specific clonotypes associated with clinical response and features related to non-responsiveness.

New vaccine candidate shows promise for protecting against Lassa fever

AI SummaryThe article discusses a new vaccine candidate called LASSARAB, developed by researchers, which shows promise in protecting against Lassa fever. LASSARAB is a deactivated or killed vaccine that effectively prevents severe cases of the disease and death in preclinical animal models. This vaccine has an advantage over other Lassa fever vaccine platforms that are… Continue reading New vaccine candidate shows promise for protecting against Lassa fever

How the immune system fails as cancer arises

AI SummaryThis article discusses the discovery of a targetable molecule that reprograms immune cells into promoting cancer. This finding sheds light on how the immune system fails as cancer arises, potentially leading to new treatment strategies to combat this process.Scientists discovered a targetable molecule that reprograms immune cells and turns them into cancer promoters.

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Categorized as Immunology

Using a molecular scissors to improve CAR-T cell therapy

AI SummaryResearchers have identified a new reason why CAR-T cell therapy fails in some cancer patients and are utilizing molecular scissors to improve the treatment’s outcomes. This discovery is leading to new strategies involving antibodies and gene editing to enhance the effectiveness of CAR-T cell therapy for patients.Researchers mined the molecular foundations of cancer and… Continue reading Using a molecular scissors to improve CAR-T cell therapy

Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

AI SummaryThe research study focuses on the use of anti-IL-10 and anti-PD-1 treatment in controlling SIV viral rebound following analytical treatment interruption in rhesus macaques. The results show that a combination of these treatments led to durable control of viral rebound in most subjects. Key findings included the induction of inflammatory cytokines, proliferation of effector… Continue reading Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption