New molecule can mimic the effects of fasting and exercise

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The research discusses a new molecule called LaKe that can mimic the metabolic effects of fasting and exercise by increasing blood concentrations of lactate and ketones in rats. This molecule could potentially offer the positive effects of exercise and fasting without the need for physical exertion or skipping meals.

The illustration to the left shows the chemical structure of LaKe. The graphs to the right show how the blood concentrations of lactate and ketones (BHB) change over time in rats that have ingested either LaKe (blue curves) or a control substance (black curves). Both lactate and BHB can be seen to increase significantly in the rats that have been given LaKe. Credit: Aarhus University/Thomas Poulsen

It is well known that regular exercise and periodic fasting have a series of positive effects on the body. Exercise and skipping meals makes for a stronger heart and reduces fat levels in the blood. The explanation lies in the body’s natural reaction in which increasing levels of lactate (the salt of lactic acid) and ketones act as efficient fuel for cells which benefit the body’s organs.

A group of chemistry, metabolism and diabetes researchers from Aarhus University has now created a molecule that can induce the same , without or fasting.

The study has just been published in the : Journal of Agricultural

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