[ASAP] Design, Synthesis, and Biological Evaluation of 5-Amino-4-fluoro-1H-benzo[d]imidazole-6-carboxamide Derivatives as Novel and Potential MEK/RAF Complex Inhibitors Based on the “Clamp” Strategy

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This article describes a study focused on designing, synthesizing, and evaluating novel 5-Amino-4-fluoro-1H-benzo[d]imidazole-6-carboxamide derivatives as potential MEK/RAF complex inhibitors. The approach is based on the "clamp" strategy, which aims to inhibit the interaction between MEK and RAF proteins. The study evaluates the biological activity of these compounds, potentially leading to the development of new therapeutic agents for targeting cancer.

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