1. When B. theta-specific T cells are transferred into# antibiotic-treated mice (# RAG1 – KO ), they become# Foxp3 + # Tregs as well as effector cells. It’s unclear if donor tg T cells were also present on the RAG1 – KO background. Host mice maintain their health. pic. twitter.com / TD0pnnxgARDavid Usharauli(@ 3DiMMUNE ) on February 9, 2019.
3. 3. The authors were able to locate a# specific # epitope in B. theta that was recognized by T cells. The SusE / SusF # lipoprotein in the outer # membrane( OM ) was predicted to be the # sequence, EEFNLPTTNGGHAT, when it was mapped in BT4295. pic. twitter.com / rH5cQHQcVNDavid Usharauli(@ 3DiMMUNE ) on February 9, 2019.
In# summary, this study demonstrated that some gut # commensal # microbiota species, in this instance # Bacteroides thetataomicron ( B. tha ), are recognized by # Tregs and even induce # effector T cell differentiation, despite the fact that the host remains healthy due to Treg regulation.David Usharauli(@ 3DiMMUNE ) on February 9, 2019.
Whether # microbiota – specific Tregs are# denovo induced or # amplified from existing ones is another issue. Personally, I believe it to be the latter. The majority of # Tregs, in my opinion, are derived from # CD25 – negative # precursors poised for Foxp3 expression & amp.David Usharauli(@ 3DiMMUNE ) on February 9, 2019.