AI Summary
This article discusses how the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm is a key factor in ALS/FTLD. It suggests that this mis-localization leads to early-stage metabolic dysfunction and progressive motor deficits similar to ALS. The study aims to better understand the role of TDP-43 in the cytoplasm and its potential contribution to ALS pathology.
The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm. However, TDP-43 gain of function in the cytoplasm is still poorly understood since TD…