AI Summary
The study explores the impact of a single dose of live, attenuated dengue vaccine on the risk of subsequent virologically confirmed dengue in children with or without prior exposure to dengue in the Philippines. Results indicate that the risk varied based on the individual's baseline dengue serostatus. While the study doesn't provide definitive guidance for public health vaccination decisions, it suggests that incomplete vaccination in children may have implications and warrants further investigation in future trials.
The risk of developing virologically confirmed dengue after a single dose of CYD-TDV varied by baseline DENV serostatus. Since the study assessed the effect of only a single dose, the findings cannot inform decisions on vaccination by public health officers. However, the findings have implications for children who receive an incomplete vaccination regimen and these results should prompt more detailed analyses in future trials on dengue vaccines.