AI Summary
This review discusses the overlap of malaria and HIV infections in sub-Saharan Africa, highlighting concerns about immunological, clinical, and therapeutic interactions. The article addresses the exacerbation of transmission and adverse outcomes associated with co-infection, as well as the need to further understand these interactions.
The geographical distribution of malaria and HIV infections widely overlap in sub-Saharan Africa, constituting a complex global health challenge. The interplay between both infections raises concerns about potential immunological, clinical, and therapeutic interactions. Both diseases have been reported to exacerbate the transmission of the other, including the possible vertical transmission of HIV in pregnant individuals with malaria. Co-infection also increases the risk of adverse outcomes such as severe malaria and death.