AI Summary
The content discusses the use of fiber photometry as a technique to study brain-behavior relationships in vivo. Initially used to report calcium dynamics, it has now expanded to include a range of fluorescent sensors for biomolecules that were previously inaccessible. This development has led to new insights into brain functions at the circuit and cell type level.
Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo. Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via genetically encoded indicators. This generated new insights into brain functions including movement, memory, and motivation at the level of defined circuits and cell types. Recently, the opportunity for discovery with fiber photometry has exploded with the development of an extensive range of fluorescent sensors for biomolecules including neuromodulators and peptides that were previously inaccessible in vivo.