AI Summary
Two populations of LDTGABA neurons regulate different reactions to unpleasant stimuli. Reelin+ neurons relay aversive stimuli to the mesolimbic DA system, while Sst-expressing neurons regulate the system through hypothalamic circuitry.
Du et al. reveal that two separate populations of LDTGABA neurons are involved in the regulation of distinct behavioral reactions to unpleasant stimuli. Long-range VTA-projecting (Reelin+) LDTGABA neurons directly relay aversive stimuli to the mesolimbic DA system. Sst-expressing LDTGABA interneurons conversely regulate the mesolimbic DA system through hypothalamic circuitry.