AI Summary
The No. 1 cause of death in children is trauma. The Trauma and Transfusion Medicine Research Center at the University of Pittsburgh is launching a clinical trial to test interventions for life-threatening bleeding in children. The trial has a budget of $34 million and aims to improve trauma care for children.
The No. 1 cause of death in children is trauma. There are an estimated 2,000 pediatric deaths from traumatic bleeding in the U.S. each year that are preventable with optimal care, yet there have been no large-scale clinical trials to guide the best way to resuscitate children with life-threatening bleeding from traumatic injury.
Until now.
The Trauma and Transfusion Medicine Research Center (TTMRC) in the Department of Surgery at the University of Pittsburgh School of Medicine is launching a clinical trial to simultaneously test multiple interventions for life-threatening bleeding in at least 1,000 traumatically injured children across 20 U.S. pediatric trauma centers. Funded by the Biomedical Advanced Research and Development Authority, part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health & Human Service, the trial has a budget of $34 million for the first five years, with the possibility to increase to more than $81 million.
This trial will be transformative when it comes to trauma care for children. Not only is trauma the leading cause of death in kids, their mortality rate with life-threatening bleeding is almost twice that of adults. And we think that’s because of delay in recognition and treatment, not that children are less resilient.”
Philip Spinella, M.D., trial co-principal investigator, co-director of the TTMRC and professor of surgery and critical care medicine at Pitt
The Massive Transfusion in Children-II (MATIC-II) is the first randomized trial to use an approach known as a “platform trial” in traumatically