RSC Medicine Accepted Manuscript, Chem., 2023
DOI: 10.1039/D3MD00192J, Research ArticleAllison L. Kempen, Nickolas R. Brauer, and Herman O. Sintim
A recently described kinase hinge binder is the 3H – pyrazolo ] 4, 3 f ] quinoline core, a privileged fusion moiety from benzodiazepine and indazole that is easily synthesized in one flask multi-component Doebner-Povarov reaction. Previous works have…
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Dual FLT3/haspin kinase inhibitor based on potent 3H-pyrazolo[4,3-f]quinoline scaffold with activities against acute myeloid leukemia
