Targeting the future: Antibody-Drug Conjugates (ADCs) in platinum-sensitive ovarian cancer in the post-PARP era

Platinum-based chemotherapy remains a cornerstone in the treatment of platinum-sensitive ovarian cancer (PSOC) due to its demonstrated efficacy in prolonging progression-free survival (PFS).1-3 Retreatment with platinum agents, especially in patients who have been exposed to poly ADP-ribose polymerase inhibitors (PARPi) presents challenges with respect to both efficacy and toxicity. Recently, novel targeted therapies, including antibody-drug conjugates (ADCs), have been examined in the platinum-resistant ovarian cancer (PROC) space.

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