Functional signatures and activation mechanisms of effector γδ T cell subsets

Genome-wide transcriptomics analysis of IFNγ-producing or IL-17A-producing γδ T cell subpopulations reveals marked differences in their mode of activation and functional potential in the periphery. We describe the differential expression of a set of 20 signature genes in models of infection and autoimmunity that may be useful for future studies on γδ T cell functions.

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