The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion. While healthy transthyretin moves hormones through blood and spinal fluid, misfolded versions of the protein form dangerous clumps in the heart and along nerves — triggering a progressive and fatal disease known as transthyretin amyloidosis (ATTR). Up to a quarter of all men over the age of 80 have some degree of ATTR, which can cause shortness of breath, dizziness and tingling or loss of sensation in the extremities. Now, scientists have uncovered new structures of transthyretin.
New structures of a critical amyloid protein illuminated
