A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study revealed that the balance between sleep and wakefulness is regulated by the action of multiple enzymes, which is an important finding when considering how to control sleep duration and sleepiness at the molecular level.
Phosphorylation and dephosphorylation enzyme groups regulate sleep and wakefulness in mammals
