Neurological conditions are the leading cause of disease burden worldwide. In 2021, about 3·4 billion individuals had disorders affecting the nervous system, with migraine accounting for the third greatest nervous-system-related loss of healthy life, assessed as number of disability-adjusted life-years.1 The International Headache Society (IHS) practical recommendations for the acute2 and preventive3 pharmacological treatment of migraine, published in August and September, 2024, are an important step towards improving management of migraine globally.