Potassium ion channel modulation at cancer-neural interface enhances neuronal excitability in epileptogenic glioblastoma multiforme

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This paper explores the interaction between glioblastoma multiforme (GBM) and the central nervous system, focusing on potassium ion channels’ role in neuronal excitability and GBM-associated epilepsy. It finds that increased KCND2 levels in OPC-like cancer cells at the cancer-neural interface, which raises extracellular potassium and increases neuronal excitability.