AI Summary
The research group developed a dual drift tube ion mobility spectrometry (DDT-IMS) technology for rapid detection of toxic metabolites from TNT, providing health warnings by detecting residual metabolites in the human body. The study focused on four metabolites produced during TNT biodegradation and demonstrated the feasibility of using this technology in detecting them in urine samples. This new approach has high potential in assessing environmental and biological risks associated with TNT.
Recently, a research group from the Hefei lnstitutes of Physical Science (HFIPS) of the Chinese Academy of Sciences developed an approach that can facilitate rapid detection of both positive and negative ions of four toxic metabolites derived from 2,4,6-trinitrotoluene (TNT), allowing for the detection of residual metabolites in the human body and providing valuable health warnings.
The research is published in the journal Talanta.
TNT undergoes biodegradation under the influence of fungi and bacteria, producing hazardous metabolites such as 2-amino-4,6-dinitrotoluene (2-ADNT), 4-amino-2,6-dinitrotoluene (4-ADNT), 2,4-diamino-6-nitrotoluene (2,4-DANT), and 2,6-diamino-4-nitrotoluene (2,6-DANT).
These metabolites pose potential health risks, making their detection critical, especially among workers in TNT manufacturing facilities.
In this study, the HFIPS group led by Prof. Huang Chaoqun developed an innovative dual drift tube ion mobility spectrometry (DDT-IMS) technology, and used it for the rapid detection of these four metabolites.
Huang and his team conducted dual-mode detection, calculated the ion mobility of the metabolites and analyzed how drift tube temperature affected the results. They also evaluated the instrument response times for both detection modes.
By applying this technology to urine samples, the researchers demonstrated the feasibility and effectiveness of DDT-IMS in detecting TNT metabolites within complex biological matrices.
The technology harbors high potential in assessing the environmental and biological risks of TNT, according to Prof. Huang.
More information: Xu Zhang et al, A study on