AI Summary
Researchers have uncovered the process by which enzymes create lasso peptides, natural products with a unique structure that provides exceptional stability. Understanding the formation of lasso peptides could lead to the development of new drugs based on these compounds for clinical use.
Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions. In a new study, researchers have constructed and tested models for how these peptides are made and demonstrated how this information might be used to advance lasso peptide-based drugs into the clinic.