AI Summary
This article discusses the evolution of the substrate specificity of an RNA ligase ribozyme from phosphorimidazole to triphosphate activation. The research focuses on understanding how this ribozyme has evolved to recognize and activate different substrates, leading to potential insights into the origins and development of RNA enzymes. This has implications for our understanding of prebiotic chemistry and the evolution of RNA-based catalysis. Studying the substrate specificity of this ribozyme can provide valuable information about the molecular mechanisms involved in RNA catalysis and the potential for engineering new RNA enzymes with unique functions.