AI Summary
Researchers have demonstrated successful control of SIV replication and reduction of viral reservoirs by combining a strict infection model with interrupting ART. This immune-based approach builds on understanding the mechanisms of action of PD1 and IL-10 in regulating HIV persistence and immune dysfunction.
Researchers have shown unprecedented control of SIV replication and decay of viral reservoirs by combining a stringent model of infection with the interruption of antiretroviral therapy (ART). The success of this immune-based approach follows the research team’s identification of the mechanisms of action for PD1 and IL-10, molecules known to regulate HIV persistence and immune dysfunction.