AI Summary
This article discusses how systemic T-cell activation and interferon-γ activity in indeterminate severe hepatitis (iSH) are similar to hemophagocytic lymphohistiocytosis (HLH). The implications of this include the potential for T-cell and interferon-γ directed therapies for treating iSH. This research highlights the importance of understanding the immune response in severe liver diseases and how it can inform potential treatment strategies.