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The article discusses how tumor cells in emerging cancers alter their gene expression to evade immune control, a process known as immunoediting. The study found that this immunoevasion could be reversed by using a DNA methyltransferase inhibitor. This research sheds light on the importance of epigenetic regulation in tumor progression and immune recognition.
Tumor cells in emerging cancers modify their gene expression to avoid immune control, a process known as immunoediting. We found that genome-wide gene expression changes in breast tumors after oncogene induction in genetically engineered mice were dominated by the epigenetic repression of innate and adaptive immune genes. Immunoevasion by tumors was reversed by a DNA methyltransferase inhibitor.
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