AI Summary
The study examines the role of cattle in the transmission of the Peste des petits ruminants virus (PPRV), which primarily infects sheep and goats. Through experimental trials and mathematical modeling, the research found that cattle play a negligible role in PPRV transmission, confirming that vaccination of small ruminants is sufficient for eradication. The study suggests continued monitoring of PPRV evolution due to the potential emergence of strains more virulent for cattle.
Peste des petits ruminants virus (PPRV) is a multi-host pathogen with sheep and goats as main hosts. To investigate the role of cattle in the epidemiology of PPR, we simulated conditions similar to East African zero-grazing husbandry practices in a series of trials with local Zebu cattle (Bos taurus indicus) co-housed with goats (Capra aegagrus hircus). Furthermore, we developed a mathematical model to assess the impact of PPRV-transmission from cattle to goats. Of the 32 cattle intranasally infected with the locally endemic lineage IV strain PPRV/Ethiopia/Habru/2014 none transmitted PPRV to 32 co-housed goats. However, these cattle or cattle co-housed with PPRV-infected goats seroconverted. The results confirm previous studies that cattle currently play a negligible role in PPRV-transmission and small ruminant vaccination is sufficient for eradication. However, the possible emergence of PPRV strains more virulent for cattle may impact eradication. Therefore, continued monitoring of PPRV circulation and evolution is recommended.
A challenge in the control and eradication of many infectious diseases is the ability of several pathogens to infect multiple host species, some of which can act as reservoirs of infection1. Pathogen control programs need to identify the role of each