AI Summary
The study published in Life Science Alliance by Texas A&M AgriLife Research scientists found that decreasing folate intake can support healthier metabolisms in aging animal models, challenging the idea that high folate consumption is universally beneficial. Folate, essential for cell growth and development, is typically added to refined grains and found in leafy greens. By limiting folate in animal models, researchers saw a decrease in cell growth processes but enhanced metabolic flexibility, potentially leading to healthier aging. The study suggests that optimal folate intake may vary based on age, supporting personalized dietary recommendations. This research could contribute to the field of precision nutrition.
In a study published in Life Science Alliance, Texas A&M AgriLife Research scientists found that decreasing folate intake can support healthier metabolisms in aging animal models, challenging the conventional belief that high folate consumption universally benefits health.
The study was led by Michael Polymenis, Ph.D., professor and associate head of graduate programs in the Texas A&M College of Agriculture and Life Sciences Department of Biochemistry and Biophysics.
Michael Polymenis, Ph.D., principal investigator, and Heidi Blank, Ph.D., first author of the study published in Life Science Alliance. This is the latest study by the researchers in their continuous investigation of the effects of folate in biological models. (Eun-Gyu No, Ph.D./Texas A&M AgriLife)
Folate, a B vitamin essential for cell growth and development, is widely recognized for its role in preventing birth defects. It’s found naturally in foods like leafy greens, and it is typically added to refined grains. Despite its prevalence, the long-term health implications of consuming high amounts of folate throughout life are unclear.
By limiting folate in animal models, the researchers saw a decrease in processes related to growth and building new cells, but enhanced metabolic flexibility, which Polymenis said could lead to healthier aging.
“Optimal folate intake may vary depending on an individual’s age,” he said. “While higher folate is crucial during early life for growth and development, a lower intake later in life may benefit metabolic health and longevity.”
The study supports the concept of precision nutrition, advocating for personalized dietary recommendations. This is a research pillar of the Texas A&M AgriLife Institute for