Fixing excess carbon dioxide: Biocatalyst-driven carboxylation under mild conditions

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The article discusses biocatalyst-driven carboxylation under mild conditions as a method for fixing excess carbon dioxide and converting it into carboxylic acids. Researchers from Tokyo Institute of Technology have demonstrated a biocatalyzed carboxylation reaction using a malic enzyme that can be tailored for selective synthesis through carbon dioxide fixation reactions. Carbon capture and utilization technologies are becoming popular as effective methods for reducing the effects of global warming.

Fixing excess carbon dioxide: Biocatalyst-driven carboxylation under mild conditions

June 10, 2024

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2 fixation products. Credit: Tokyo Institute of Technology”> Biocatalytic carboxylation by malic enzyme new avenues for selective synthesis of wider CO2 fixation products. Credit: Tokyo Institute of Technology

Carbon capture and utilization technologies for the conversion of carbon dioxide into carboxylic acids have garnered attention recently, with researchers from Tokyo Tech recently demonstrating a biocatalyzed carboxylation reaction of not only natural substrate, pyruvate, but also an unnatural one, 2-ketoglutarate, using Thermoplasma acidophilum NADP+- malic enzyme under mild reaction conditions. The proposed strategy can be tailored for the selective synthesis through carbon dioxide fixation reactions.

Removing the excess carbon dioxide (CO2) from the environment is not the end goal of the decarbonization process necessary to reduce the effects of global warming caused by the greenhouse gas. Rather, novel and utilization (CCU) technologies are gaining popularity in the current decade as an effective method for

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