AI Summary
This study demonstrates that hippocampal cholecystokinin-expressing interneurons play a crucial role in regulating temporal coding and contextual learning. Silencing these interneurons disrupted theta oscillation-related temporal coding during exploration, enhanced sleep replay, and improved recall of contextual fear memories. This research highlights the significance of these specific interneurons in memory processes and spatial navigation.
Rangel Guerrero et al. silenced the activity of CA1 Cholecystokinin-expressing interneurons. Optogenetic silencing disrupted the theta oscillation-related temporal coding of place cells during exploration while sleep replay was enhanced. Chemogenetic silencing enhanced the recall of contextual fear memories the next day and enabled the differentiation of similar environments.