AI Summary
This article discusses a thermoresponsive polymeric hydromorphone prodrug that provides sustained local analgesia without apparent adverse effects. The prodrug's unique properties allow for controlled release of hydromorphone, a powerful opioid analgesic, at the site of administration. This could potentially improve pain management with reduced risk of systemic side effects.
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.3c01133