AI Summary
This article discusses the rising incidence of early-onset colorectal cancer (EOCRC) and the unknown causes behind this trend. The study conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian randomization analyses to explore genetic and causal risk factors associated with EOCRC. The research aims to provide insights into the causes of EOCRC and identify common genetic variants and modifiable risk factors underlying the disease.
The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. Colorectal cancer (CRC) has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian randomization analyses to explore germline genetic and causal modifiable risk factors associated with EOCRC.