AI Summary
This article discusses using nanobodies to target the transporter SPNS2, which plays a role in releasing S1P signaling molecules to regulate inflammatory responses. By enlarging the SPNS2 structure, scientists were able to view the S1P molecules and analyze the protein at an atomic level. This research could provide valuable insights into the mechanisms underlying inflammation and immune regulation.
Using specially-developed nanobodies that bind to SPNS2 and enlarge the entire structure, the enlarged SPNS2 structure allows the S1P molecules to be viewed via cryogenic electron microscopy. Scientists have analyzed the structure of the SPNS2 protein at an atomic level that could provide greater insights into how S1P signalling molecules are released to communicate with the immune cells to regulate inflammatory responses.