AI Summary
The content provided discusses the importance of sleep disturbances in immune-mediated encephalitides, specifically anti-IgLON5 disease and NMDA receptor antibody encephalitis. People with anti-IgLON5 disease experience disrupted sleep initiation, altered sleep stages, and non-rapid-eye-movement (NREM) sleep. Rapid-eye-movement (REM)-sleep behavior disorders (RBDs) and sleep breathing disorders are also common in this condition. Sleep patterns and disturbances are considered important features to consider in the diagnosis and management of these immune-mediated encephalitides.
Sleep disturbances are an important feature in various immune-mediated encephalitides,1 with disease-specific characteristics (eg, as in anti-IgLON5 disease or NMDA receptor antibody encephalitis).2,3 People with anti-IgLON5 disease, for example, have disease-typical change in sleep patterns with disrupted sleep initiation and strongly altered sleep stages, which are referred to as undifferentiated, non-rapid-eye-movement (NREM) sleep. Rapid-eye-movement (REM)-sleep behaviour disorders (RBDs) and sleep breathing disorders are also common in people with this immune-mediated encephalitis.