AI Summary
The article discusses the role of the intracellular peptide Pcp4a in regulating feeding state-dependent behavioral choices in zebrafish. It is found that food intake represses the expression of pcp4a through dopamine D2 receptor activation, leading to disinhibition of CaMKII and potentially increased weakening of responses to small visual stimuli. This research sheds light on the complex mechanisms underlying feeding behavior and behavioral choices in zebrafish.
Zaupa et al. identify the intracellular peptide Pcp4a as a mediator of the modulatory action of feeding state on behavioral choice. Food intake represses expression of pcp4a via activation of dopamine D2 receptors, leading to disinhibition of CaMKII and possibly increased CaMKII-dependent weakening of responses to small visual stimuli.