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The Xue Lab has made a breakthrough in understanding the immune system and how it can be used to fight diseases. They have identified a specific protein, Tle3, that regulates the training and effectiveness of central memory T cells. By releasing the regulation of Tle3, they were able to accelerate the formation of these T cells, resulting in a stronger immune response. This discovery has implications for developing better vaccines and cancer treatments in the future.
The Xue Lab at the Hackensack Meridian Center for Discovery and Innovation (CDI) has made another breakthrough in better understanding, and potentially modulating, the immune system to fight diseases.
The insights into a specific protein and how it regulates the training and efficacy of central memory T cells are published by Hai-Hui (Howard) Xue, a member of the CDI, in the journal Nature Immunology.
The immunological implications could produce better vaccines and cancer treatments in the future, according to the Xue lab, which is also part of the Institute for Immunologic Intervention (3i) at the CDI.
The molecular focus is on the transducin-like enhancer (Tle) family of proteins. Specifically, their inquiry homed in on Tle3, and how it exactly functions in the training of T cells.
Their observations in preclinical models, both ex- and in-vivo, showed consistently that Tle3 functioned as a mediator and regulator of complex interactions which allow antigen-experiencedT cells to be specialized in response to foreign threats – and thereby become central memory T cells that are more efficacious in protection.
By releasing the “brakes” of Tle3’s regulation, Xue and the team were able to accelerate the formation of central memory T cells and hence supercharge immune response.
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The implications could allow future manipulation of the immune system – by releasing the brakes and unleashing T cells to faster and more forcefully respond to threats, including both infectious disease and cancer, according to the paper.
“In sum, Tle3 uses dual functions in gene regulation